PFKFB4 and Familial prostate cancer: Depletion of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 4 (PFKFB4) resulted in a significant decrease in the levels of Dihydronicotinamide‐adenine dinucleotide phosphate (NADPH) that maintain cellular stores of reduced glutathione antioxidant, leading to increased accumulation of ROS in prostate cancer cells 38.