Depletion of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 4 (PFKFB4) resulted in a significant decrease in the levels of Dihydronicotinamide‐adenine dinucleotide phosphate (NADPH) that maintain cellular stores of reduced glutathione antioxidant, leading to increased accumulation of ROS in prostate cancer cells 38. The gene discussed is PFKFB4; the disease is prostate cancer.