RPS6KB1 and cancer: Because the EMT process can be regulated by a diverse array of cytokines and growth factors [14], we analyzed the activation status of several kinases and their effectors involved in cancer cell proliferation and survival, including EGFR, IGF-1R, Src, FAK, Akt, Erk1/2, mTOR, MEK1/2, and p70S6K.