To investigate the correlation between CCL18 expression and tumor angiogenesis, we performed double immunohistochemical (IHC) staining for CCL18 expression using anti-CCL18 antibodies and microvascular density (MVD) using anti-CD34/CD31/von Willebrand Factor (vWF) antibodies in 80 primary invasive ductal carcinoma samples of the breast. This evidence concerns the gene VWF and neoplasm.