FDA approved recently two products, the CD30-targeting ADC brentuximab-vedotin for the treatment of relapsed Hodgkin lymphoma and of anaplastic large cell lymphoma [17], and ado-trastuzumab emtansine (T-DM1) for the treatment of HER2/neu-positive metastatic endometrial cancer [18]. The gene discussed is ERBB2; the disease is anaplastic large cell lymphoma.