It is not clear whether the poor prognosis is attributable to the MYC rearrangement itself, or due to the fact that 58%-83% of MYC translocated DLBCL also had dual or even triple translocations that target BCL2 and/or BCL6. High MYC amplifications copy number alterations also have been associated with shorter overall survival [79]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.