Ruzinova et al found that a primarily nuclear or mixed nuclear and cytoplasmic staining pattern for Myc in an aggressive B-cell lymphoma is highly predictive of a MYC translocation (positive-predictive value = 0.92, negative-predictive value = 0.95, P < 0.0001) and showed that the subcellular localization of Myc can be determined with good interobserver agreement among pathologists (k statistic = 0.90) [59]. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.