BRD4 and paracoccidioidomycosis: Although BRD4 binds to a high number of enhancers and promoters, its inhibition is particularly sensitive in very large and active enhancers called super-enhancers that regulate oncogenes such as MYC. The addiction of PCM cells to MYC makes the cells particularly sensitive to the BRD4 binding disruption on its super enhancer [41].