Virtually all lymphomas with MYC deregulation are of B-cell lineage and include Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and BL (BCL-U), plasmablastic lymphoma, transformed follicular lymphoma, and rare de novo acute lymphoblastic lymphoma/leukemia (ALL). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.