To further investigate the effect of TAZ on pancreatic cancer development and progression, we generated BxPC-3 and AsPC-1 cells with stable overexpression of TAZ (BxPC-3/AsPC-1-pBABE-TAZ) and PANC-1 and FG cells with stable depletion of TAZ (PANC-1/FG-Sh-TAZ-1 and -Sh-TAZ-2) (Figure 2A). The gene discussed is WWTR1; the disease is familial pancreatic carcinoma.