In this report we show that typical ultraviolet (UV) signature mutations in the promoter region of DPH3 and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes (henceforth, called DPH3 promoter mutations), adjacent and within a preexisting Ets binding site, occur not only in melanoma but are common in basal cell (BCC) and squamous cell (SCC) carcinomas of skin. Here, DPH3 is linked to melanoma.