In this report we show that typical ultraviolet (UV) signature mutations in the promoter region of DPH3 and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes (henceforth, called DPH3 promoter mutations), adjacent and within a preexisting Ets binding site, occur not only in melanoma but are common in basal cell (BCC) and squamous cell (SCC) carcinomas of skin. This evidence concerns the gene OXNAD1 and skin basal cell carcinoma.