In all sets of cell lines, expression of mesenchymal markers correlated with increased expression of the transcription factors Twist1 or Twist2, ZEB1, and ZEB2, which suggests that multiple transcription factors may participate in the induction and maintenance of the EMT phenotype in these cellular cancer models (Figure 6A–6C, Supplementary Figure S7A–S7B). The gene discussed is TWIST1; the disease is cancer.