LGR5 and neoplasm: In this population, we found significant association of LGR5 with markers of tumor aggressiveness, including primary tumor size (p = 0.010), lymph node metastases, and N stage (p < 0.0001), number of nodal metastases (< 0.0001), T Stage (p = 0.0104), vascular invasion (p < 0.0001), microscopic extra-thyroidal extension (p < 0.0001), capsular invasion (p = 0.0140), and macroscopic invasion (p = 0.007) [Table 2].