We believe that IL-22-producing T cells, especially γδ T cells, play the most important role in the exacerbation of skin inflammation in neoATB mice, whereas down-regulation of IL-22-prodcuing T cells may be an important factor responsible for the improvement/reduction of the skin inflammation in adultATB (although IL-17 producing T cells cannot be completely excluded in the adult treatment model). This evidence concerns the gene IL22 and dermatitis.