To confirm the role of IL-22 in the exacerbated psoriasis in neoATB mice, we intradermally injected anti-IL-22 (neoATB+αIL-22) or isotype control antibodies into neoATB mice at days 1 and 3 during imiquimod treatment (see treatment scheme on Supplementary Fig. 7a). This evidence concerns the gene IL22 and psoriasis.