Reported associations of TLR2 genetic variants with Alzheimer’s disease (Yu et al. 2011), onset age of bipolar disorder (Oliveira et al. 2015), and cognitive function in schizophrenia (Kang et al. 2013) are highly suggestive of genetically driven interindividual ability to modulate neuroinflammatory processes. Here, TLR2 is linked to bipolar disorder.