The t(X; 17) (p11.2; q25) or TFE3-ASPL translocation in RCC and alveolar soft part sarcoma (ASPS) contain the identical TFE3-ASPL fusion transcript; however, the t(X; 17) translocation is consistently balanced (reciprocal) in the Xp11.2 translocation RCC and unbalanced in the ASPS [11]. Here, TFE3 is linked to alveolar soft part sarcoma.