In agreement with the Tbr2 KO model, the irradiated mice showed increased locomotor activity during the night (Supplementary Fig. 3b) and reduced anxiety in the EPM with no difference in activity measured by travel distance and total arm entries (Fig. 2a,b and Supplementary Fig. 4b,d; for absolute values see Supplementary Fig. 6). The gene discussed is EOMES; the disease is Anxiety.