TRIM21 and systemic lupus erythematosus: They found that autoantibodies targeting to several nuclear antigens (e.g., dsDNA, dsRNA, histone H2A, histone H2B, SS-A, and ssDNA) showed distinctively lower levels in patients with DLE (DLE+SLE+ and DLE+SLE−) than in SLE patients without DLE (DLE−SLE+), implying that DLE is a phenotypic marker associated with mild systemic disease.