TNFAIP3 and systemic lupus erythematosus: Tavares et al. used protein arrays to analyze the autoantibodies in sera from conditionally-knockout mice and showed that mice with A20 deficiency in B cells possessed more germinal center B cells, autoantibodies, and increased expression of anti-apoptotic proteins such as Bcl-x, alluding to the role of A20 in B cell survival and lupus [46].