They further validated by using ELISA that the positive rate of anti-CLIC2 in SLE was 28.18% and the level of anti-CLIC2 in SLE was positively correlated with disease activity in terms of SLE Disease Activity Index (SLEDAI) score and several other indexes (P < 0.05) [50]. The gene discussed is CLIC2; the disease is systemic lupus erythematosus.