The IgG autoantibody profile in DLE+SLE− subjects is similar to that in HCs, although a few, including three autoantibodies against nuclear antigens (Jo-1, U1-snRNP-A, and SS-A) and two against epidermal–dermal junction proteins (HSPG and α6β4 integrin), showed slightly higher levels. Here, TRIM21 is linked to systemic lupus erythematosus.