In addition, CC genotype of rs2108552 and T-C-T-C haplotypes in Numb gene is a possible risk genetic marker for CAD, and G allele and G-T-C-C haplotypes is a possible risk genetic marker for CAD among male Han Chinese which supports the hypothesis that Numb gene variations are involved in the pathogenesis of CAD. This evidence concerns the gene NUMB and coronary artery disorder.