We reanalyzed cancer genomes from 44 previously published SHH-MBs (Jones et al, 2012; Rausch et al, 2012a; Kool et al, 2014) and additionally generated 30× coverage tumor and matched blood WGS data for a recently diagnosed SHH-MB patient with a germline mutation in TP53 (MB243). Here, TP53 is linked to cancer.