CEP-701 inhibited TrkAIII tyrosine phosphorylation and significantly increased localization of 100kDa TrkAIII to 45.6±4.5% in GN membranes (fractions 1 and 2; versus untreated controls P = 0.019, df = 6) and significantly reduced TrkAIII in COP-membranes to 25.7±2.6% (fractions 3 and 4; versus untreated controls P = 0.0065, df = 6) and in ER-membranes to 28.7±2.9% (fractions 5 and 6 versus untreated controls P = 0.0035, df = 6), indicating increased transport to the GN (Figure 3D I-II). The gene discussed is CARD16; the disease is ganglioneuroma.