CARD16 and ganglioneuroma: Total TrkAIII levels (100kDa plus 120kDa) were, therefore, significantly reduced to 22.1±2.9% in ER membranes (fractions 5 and 6; versus untreated controls at 60 minutes P < 0.0001, df = 6) and to 17.1±2.2% in COP membranes (fractions 3 and 4; versus 60 minutes untreated controls; P = 0.0012, df = 6), and significantly increased to 60.6±7.8% in GN membranes (fractions 1 and 2; versus 60 minutes untreated controls P < 0.0001, df = 6).