AKT1 and neoplasm: The subsequent and altered oncogenic signalling through PI3K/Akt but not Ras/MAPK results in increased survival, a pattern of malignant gene expression, increased genetic instability and promotion of stem cell-like behaviour rather than differentiation [1, 3, 4, 6, 35], which together not only promote tumour progression but may also be involved in tumour initiation.