NTRK1 and ganglioneuroma: Together, these data indicate that: TrkA inhibitors promote GN-associated TrkAIII 120kDa maturation; 120kDa TrkAIII is more sensitive than 100kda TrkAIII to degradation at the proteasome; 120kda TrkAIII is stabilised by GA sensitive interaction the Hsp90 adding to our report that TrkAIII exhibits GA-sensitive interaction with Hsp90 [2], and that cell surface expression of 120kDa TrkAIII is prevented by its degradation at the proteasome.