Secondly, Sanger sequencing of synovial sarcomas has revealed mutations in several cancer-related genes, including TP53, TERT, CDH1, CTNBB1, APC, HRAS, PTEN, PI3KCA, EGFR, BCL9, SETD2, TRRAP and PDGFRA (Table 1). This evidence concerns the gene SETD2 and cancer.