BIRC5 and cancer: Although suppression of other anti-apoptotic proteins such as Bcl-2 family members and survivin sensitizes cancer cells to TRAIL-induced apoptosis [30], JQ1 did not decrease the levels of Bcl-XL, Mcl-1 and survivin in every tested cell lines except for weak effects on reducing Bcl-2 in H1299 and A549 cells.