However, in some apoptosis-resistant cancers, other non-specific autophagy inducers such as 4-hydroxytamoxifen (OHT) and Bcl-XL-inhibitor Z36 triggered autophagic cell death by K-Ras autophagic degradation and disrupting the interaction between Bcl-XL and Beclin1, therefore playing a significant role in killing tumor cells [137, 177]. The gene discussed is BCL2L1; the disease is cancer.