MSH2 and Familial adenomatous polyposis: This began with the identification of the adenomatous polyposis coli gene (APC) 2, in which germline mutations cause familial adenomatous polyposis (FAP), followed by the discovery of other genes such as MSH2 in Lynch syndrome 3 and mutY homologue (MUTYH ) in MUTYH‐associated polyposis (MAP) 4 (also called MYH‐associated polyposis).