Interestingly, C4A and MDK are previously characterized circulating biomarkers for HCC [1] whereas SERPINC1 (also prioritized as a potential biomarker in our study) is an interacting partner of AFP, C8A, F2, UPB1, F10, AHSG, APOA5, APOC3 and IGFBP1 (involved in cancer progression) (Fig 4). Here, IGFBP1 is linked to hepatocellular carcinoma.