The ROC curves documented a significant statistical correlation of the proposed candidate biomarkers with MBL2, C8A, SERPINC1, HSD11B1, ADH6, UPB1 and CYP2A6 levels predicting HCC-free survival considerably well {area under ROC = 0.861 (KM), and area under ROC = 0.854 (NNE)}, while no significance was found for AFP and HCC-free survival rate (area under ROC = 0.354 (KM), and area under ROC = 0.5 (NNE). This evidence concerns the gene HSD11B1 and hepatocellular carcinoma.