TP53 and metabolic syndrome: Multiple in vivo, in vitro, and cohort-based reports over the last two decades show that, in addition to being anti-inflammatory, HCQ has multiple other properties that include beneficial effects on vascular compliance and endothelial function,[14] insulin resistance, metabolic syndrome,[15–17] and immune dysfunction.[18, 19] Recently when studying the p-53 based stress signaling in the metabolic syndrome, investigators have found signals for a possible anti-atherosclerosis effect for HCQ in presence of normal renal function[17].