HAVCR2 and acute myeloid leukemia: We found that, in primary AML cells, mTOR S2448 phosphorylation was substantially increased upon exposure to SCF as well as to anti-Tim-3 antibody stimulation (about 50% of SCF-induced effect), while LPS displayed a weaker ability to upregulate the intracellular levels of phospho-S2448 mTOR.