Reportedly, CXCR7 modulates CXCR4 signaling and enhances CXCL12-induced cell migration and metastasis of breast cancer cells [13, 14], and LCP1 is implicated in the CXCL12-induced migration of chronic lymphocytic leukemia cells [26]. Here, ACKR3 is linked to B-cell chronic lymphocytic leukemia.