Consistent with our finding in a mouse model system that GLI1 enhanced the lung metastasis of mouse breast cancer cells, GLI1 enhanced CXCL12-induced migration of human breast cancer cells, and the migration was suppressed by any of CXCR4-specific inhibitor AMD3100 treatment, CXCR7 knockdown, or LCP1 knockdown. The gene discussed is CXCL12; the disease is breast cancer.