Pretreatment of CLL B-lymphocytes with AG490 or P1-TKIP peptide strongly prevented CXCL12-triggered LFA-1 transition to low-intermediate (Figure 6E and Supplementary Figure S1E) and to high affinity states induced by CXCL12 (Figure 6F and Supplementary Figure S1F). Here, CXCL12 is linked to B-cell chronic lymphocytic leukemia.