Chronic treatment with these agents for 30 weeks diminished Shh signaling by an average of 80, 60 and 47%, respectively by vismodegib, ITRA and cyclopamine However, differences in their ability to inhibit BCC growth (both microscopic and macroscopic) were subtle (60–70%) and did not correlate with their inhibitory effect on Shh pathway genes (figure 4E). Here, SHH is linked to skin basal cell carcinoma.