Furthermore, employing both genetic and pharmacological approaches, we showed in a murine model of UVB-induced skin carcinogenesis and in patients with NBCCS that overexpression of COX-2 accompanies accelerated BCC growth whereas NSAID-induced COX-2 inhibition by celecoxib partially (30–50%) abrogates growth of these tumors [59, 85, 95]. Here, PTGS2 is linked to skin basal cell carcinoma.