The present study was designed to evaluate the effect of supplemented LA diet (1 g/kg) on: 1- the expression of kinin B1 and B2 receptors at mRNA and protein levels in diabetes target organs (liver, pancreas, gastrocnemius skeletal muscle, white retroperitoneal adipose tissue); 2- superoxide anion production (O2•−) and NADPH oxidase activity (aorta and epididymal adipose tissue); and 3-plasma levels of glucose and insulin, insulin resistance (HOMA index) and body weight in ZDF rats. This evidence concerns the gene FMO5 and diabetes mellitus.