In the present study, LA treatment was found to have no effect on hyperglycemia, hyperinsulinemia as well as the insulin resistance index even though it prevented completely the rise in superoxide anion production and NADPH oxidase activity in aorta and adipose tissue as well as the upregulation of B1R expression in liver and gastrocnemius muscle of ZDF rats. Here, FMO5 is linked to hyperinsulinism.