EWSR1 rearrangements have been documented in many soft tissue neoplasms, including Ewing's sarcoma/primitive neuroectodermal tumor (EW/PNET), DSRCT, low grade myoid tumor, myxoid liposarcoma, extraskeletal myxoid chondrosarcoma, sclerosing epithelioid fibrosarcoma, myoepithelial tumor, angiomatoid fibrous histiocytoma, clear cell sarcoma of soft tissue, clear cell sarcoma-like tumor of gastrointestinal tract, and primary pulmonary myxoid sarcoma. The gene discussed is EWSR1; the disease is soft tissue neoplasm.