Interest in a therapeutic role of oxygen in acute ischemic stroke (AIS) has recently been kindled by the results of over 120 animal studies[2-8] and pilot human studies[9-11] suggesting that the delivery of high-flow oxygen promptly after symptom onset (normobaric oxygen therapy, or NBO) affords neuroprotection and may have therapeutic potential by increasing the 3-hour time window for thrombolysis with intravenous tissue plasminogen activator (IV tPA). Here, PLAT is linked to androgen insensitivity syndrome.