GNAQ and ovarian carcinoma: Therefore, in the present study, we examined the role of Gαi2, Gαq, Gα12, and Gα13 in ovarian cancer cell proliferation and migration in vitro and their tumorigenic role in xenograft tumors in vivo, by utilizing SKOV3 cells expressing nonspecific scrambled shRNA (SKOV3 NS) control cells and the respective Gα-silenced SKOV3 cells (shGαi2, shGαq shGα12, and shGα13).