An important work in this category by Zhang et al has substantially contributed to the understanding of the mechanisms that underlie MET-dependent tumor-associated angiogenesis by showing that MET signaling directly up-regulates transcriptional activation of the VEGF gene and in parallel down-regulates the expression of thrombospondin-1, an angiogenesis suppressing factor [22]. The gene discussed is VEGFA; the disease is neoplasm.