Taking into consideration the important emerging role of MET-dependent signaling in liver cancer pathogenesis with particular emphasis on MET-associated tumor vascularization, we investigated in the current study the potential of the MET TKIs to control growth and angiogenesis in models of MET-driven liver tumors, which consist of isogenic cell lines that ectopically express MET mutated variants that differ exclusively by their responsiveness to MET targeting. This evidence concerns the gene MET and liver cancer.