MET and neoplasm: Taking into consideration the important emerging role of MET-dependent signaling in liver cancer pathogenesis with particular emphasis on MET-associated tumor vascularization, we investigated in the current study the potential of the MET TKIs to control growth and angiogenesis in models of MET-driven liver tumors, which consist of isogenic cell lines that ectopically express MET mutated variants that differ exclusively by their responsiveness to MET targeting.