RIOX2 and lung carcinoma: By evaluating mdig/MINA expression through immunohistochemistry of the cancer tissues and the overall survival of 101 lung cancer patients, studies by Komiya et al. [23] revealed that patients who stained negative for mdig/MINA had significantly shorter survival than those who were stained positive for mdig/MINA, especially in stage I or squamous cell carcinoma, indicating that increase of the protein level of mdig/MINA may be associated with a favorable prognosis of lung cancer patients.