We found 2 remarkably well conducted RCTs without benefits in low inflammatory conditions (old age and obesity) that met most of our proposed criteria (initial 25(OH)D<50 nmol/L, final 25(OH)D >75 nmol/L; baseline CRP elevated, and physiological doses of vitamin D3 used). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.