CHAT and juvenile Huntington disease: For example, (i) downregulation of ChAT activity causes serious cholinergic disease such as dementia, schizophrenia, and Huntington's disease [5–7], (ii) ChAT abnormalities in the brain could lead to sudden death in infants [3], and (iii) ChAT inhibition leads to generation of Alzheimer's disease because ChAT is the enzyme that is responsible for ACh synthesis.