It has been reported that Myc gene amplification and overexpression occurs in post-irradiation induced angiosarcomas, but not in primary cutaneous angiosarcomas or in other radiation-associated vascular proliferations [35, 36]; however several other studies provide evidence that Myc amplification and overexpression is not a definitive marker of radiation-induced tumorigenesis in angiosarcomas [37–39]. This evidence concerns the gene MYC and angiosarcoma.