In addition, motif analyses on accessible chromatin regions by FAIRE-seq identified motifs for a large range of other transcription factors previously linked to prostate cancer development and progression, including CTCF, SP1, FOS, and ETS domain family of transcription factors (Shemshedini et al, 1991; Lu et al, 2000; Taslim et al, 2012; Chen et al, 2013). This evidence concerns the gene SP1 and Familial prostate cancer.