The more rapid onset of bone marrow failure in Adh5−/−Fancd2−/− compared to Aldh2−/−Fancd2−/− mice, in addition to the involvement of additional tissues, suggests that the compound(s) detoxified by ADH5 are much more potent or abundant genotoxins than those cleared by ALDH2 (Figures 7A, S7E, and S7F). The gene discussed is ADH5; the disease is Bone marrow hypocellularity.