Indeed, as our analysis demonstrates, 41.3% of patients harboring a homozygous risk allele genotype (CC) at the CFH Y402H locus showed good response with anti-VEGF treatment compared with 48.9% of heterozygotes (CT) and wild-type homozygotes (TT), and the result was statistically significant, indicating that anti-VEGF treatment was less effective in AMD patients with the CFH CC genotype. The gene discussed is VEGFA; the disease is age-related macular degeneration.