According to these comprehensive data sets, Mx1 mutations have been discovered in a number of common cancer types, including colorectal cancer [19–22], head and neck squamous cell carcinoma [23], follicular lymphoma [24], cutaneous squamous cell carcinoma [25], mantle cell lymphoma [26], embryonal rhabdomyosarcoma [27], renal cell carcinoma [28], prostate cancer [29], lung adenocarcinoma [30], melanoma [31], medulloblastoma [32], and ovarian carcinoma [33]. This evidence concerns the gene MX1 and hereditary clear cell renal cell carcinoma.