Among the top 20 ABF signals, half are within/near genes known to have prior genome‐wide significant associations with obesity, BMI, and/or weight, while the P‐value approach assigns rank 29 to one of these signals (rs13107325 in SLC39A8/ZIP8, a zinc transporter). Here, SLC39A8 is linked to obesity due to melanocortin 4 receptor deficiency.