In the present study, we confirmed the upregulation of PAK4 in the tumor tissues than in the peritumor tissues in 93 cases of cervical cancers; and the PAK4 upregulation was markedly associated with the FIGO stage, lymph node metastasis, distant metastasis and histological grade of these cervical cancer patients, was significantly and independently prognostic for the overall survival time of these patients. Here, PAK4 is linked to cervical cancer.