We also aimed to transform these hybrid nanoparticles into an active targeted platform for delivery of siRNAs to NTSR1 expressing tumors by covalently attaching anti-NTSR1-mAb to the surface of these nanoparticles and to confirm the involvement of NTSR1 in the uptake of these nanoparticles by cancer cells. The gene discussed is NTSR1; the disease is cancer.