ADRB2 and obesity due to melanocortin 4 receptor deficiency: The prevalence of overweight in the Brazilian population aged between 10 and 19 is20.5%,23 whereas 10.3% of children and 13.8%of adolescents have asthma.24 Genetic factorshave been demonstrated to contribute to the development of obesity and asthma duringchildhood, but the roles of specific genes and their interaction are still largelyunknown.3,4,15 The Arg16Gly andGln27Glupolymorphisms in the ADRB2 gene have beenrelated to the development of overweight9 andasthma exacerbations.11,12