Wild-type Nav1.7 is not an efficient generator of resurgent sodium currents [15] despite having similar kinetics of open-state inactivation to Nav1.6 [67], but mutations identified in patients with Paroxysmal Extreme Pain Disorder can substantially increase Nav1.7 resurgent currents [15, 44, 68]. Here, SCN8A is linked to paroxysmal extreme pain disorder.