GRN and Alzheimer disease: It is well established that GRN gene mutations are associated with various kinds of neurological degenerative diseases, such as frontotemporal lobar dementia (FTLD), Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (Baker and Manuelidis, 2003; Lopez de Munain et al., 2008; Malaspina et al., 2001; Vercellino et al., 2011).