In a rat model of RA, adjuvant-induced arthritis, remarkable changes in skeletal muscle have been demonstrated [24–30], including increased mRNA expression of tumor necrosis factor (TNF)-α, muscle ring-finger protein (MuRF1), atrogin1, insulin-like growth factor (IGF)-1, MyoD and myogenin in relation to muscle wasting and a reduced body weight gain during growth. This evidence concerns the gene TNF and rheumatoid arthritis.