Interestingly, in a detailed study of obese individuals with or without insulin resistance Kloting et al. demonstrated that insulin sensitive obesity was characterized by smaller adipocytes, higher secretion of adiponectin and reduced adipose tissue inflammation, in fact, the strongest predictor of insulin sensitivity was the combination of adiponectin and cellular markers of inflammation, markers that were distinctive also in the present study [30]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.