However, the rates of immune-related Grade 3/4 elevations in ALT (21 %) and AST (17 %) reported in that study [12] were higher than Grade 3/4 hepatic irAEs previously reported in mostly Caucasian patients receiving IPI monotherapy at 3 or 10 mg/kg (0–12 %) [7, 15, 19]. Here, GPT is linked to Hepatitis.