GPT and colitis: However, the rates of Grade 3/4 hepatic events were higher [elevated alanine aminotransferase (ALT) level, 22 % in study CA184-024 versus 8 % in previous studies; elevated aspartate aminotransferase (AST) level, 18 % vs. 7 %], and the rates of Grade 3 or 4 gastrointestinal (GI) events were lower (rate of diarrhea, 4 % vs. 11 %; rate of colitis, 2 % vs. 5 %) than expected based on prior studies.