Recent data from our lab and others indicate that salivary concentrations of IL-6, IL-8, albumin, calprotectin, PGE2, MMP-8, and MIP-1α are elevated in patients who have gingivitis.[10, 60] Accordingly, these salivary analytes appear to serve as biomarkers of gingivitis, coupled with existing literature on biomarkers of periodontitis [52, 59–63], may help to discriminate those patients who are transitioning from health to gingivitis and on further to periodontitis. This evidence concerns the gene MMP8 and gingivitis.